Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development
摘要：
Although most investigators agree that the CD4- CD8- CD3- thymocyte subset represents the most immature intrathymic T cell capable of repopulating the thymus in vivo, little is known of the earliest stages of human T-cell development. Using mAbs to hematopoietic and T-cell lineage molecules in quantitative immunofluorescence studies, new insight has been gained regarding the phenotype of human T-cell precursors before and after colonization of human thymic rudiment. In this article, Barton Haynes and colleagues discuss the sequential expression of CD7, CD4, CD8, CD3, CD2, CD1, CD45, TCRγδ and TCRαβ, and propose a model defining the stages of T-cell precursors during fetal ontogeny.
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关键词：
Humans T-Lymphocytes Hematopoietic Stem Cells Antigens, Differentiation, T-Lymphocyte Embryonic and Fetal Development Antigens, CD7 Models, Biological
DOI：
10.1016/0167-5699(89)90232-6
被引量：
年份：
1989
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