Protein Tyrosine Phosphatases in the Human Genome
摘要：
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.
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关键词：
Humans Tyrosine Phylogeny Signal Transduction Protein Structure, Tertiary Phosphorylation Gene Expression Regulation, Enzymologic Amino Acid Sequence Protein Tyrosine Phosphatases Genome, Human
DOI：
10.1016/j.cell.2004.05.018
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2004
Elsevier
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