Method for preparing modified release pharmaceutical compositions
申请(专利)号：
10/574125
申请日期：
10/04/2004
公开/公告号：
US20070122482
公开/公告日期：
05/31/2007
被引量：
摘要：
A method for the preparation of a pharmaceutical particulate composition for modified release of one or more therapeutically, prophylactically and/or diagnostically active substances, the method involving spraying of a composition comprising an oily material on a solid composition in order to subject the solid composition to a controlled agglomeration process, whereby individual particles are aggregated into agglomerates in a controlled manner and a relatively small particle size and particle size distribution is obtained, the particulate composition comprising a sufficient amount of at least one release-rate modifying substance to provide a modified release of the active substance sufficient to provide duration of therapeutic, prophylactic and/or diagnostic effect of at least about 2 hours when the composition is exposed to an aqueous environment.
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