Fat-binding polymers
申请(专利)号:
US20020307151
申请日期:
2002-11-27
公开/公告号:
US2003175236A1
公开/公告日期:
2003-09-18
申请(专利权)人:
MANDEVILLE W. HARRY;WHITESIDES GEORGE M.;HOLMES-FARLEY STEPHEN RANDALL
被引量:
摘要:
The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inibitors, for example, lipstatin and tetrahydrolipstatin.
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