Expression of macrophage migration inhibitory factor in human glomerulonephritis
摘要：
Renal MIF expression is markedly up-regulated in proliferative forms of human GN, and this correlates with leukocyte infiltration, histologic damage, and renal function impairment. These results suggest that MIF may be an important mediator of renal injury in progressive forms of human GN. Based on these findings, together with the known pathogenic role of MIF in experimental GN, we propose that MIF is an attractive therapeutic target in the treatment of progressive forms of GN.
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关键词：
Glomerulonephritis, Membranoproliferative Glomerulonephritis, Membranous 肾小球肾炎, 膜增生性 肾小球肾炎, 膜性 巨噬细胞游走抑制因子
DOI：
10.1046/j.1523-1755.2000.00869.x
被引量：
年份：
2000
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