A COMPOSITION CONTAINING A TETRACYCLINE AND USE FOR INHIBITING ANGIOGENESIS
申请(专利)号:
AU19920014119
申请日期:
1992-01-15
公开/公告号:
AU1411992A
公开/公告日期:
1992-08-27
申请(专利权)人:
HENRY BREM
被引量:
摘要:
Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a tetracycline or tetracycline such as minocycline. The effective dosage for inhibition of angiogenesis based on in vitro testing is between one and 500 micromolar. The compositions are delivered topically, locally or systemically using implants or injection. The composition is extremely selective for growth of endothelial cells, inhibiting growth, but is not cytotoxic at the effective dosages.
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