Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
摘要：
Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine kinases. Here, we report the requirement for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Both receptors can bind mDab1 on their cytoplasmic tails and are expressed in cortical and cerebellar layers adjacent to layers that express Reelin. mDab1 expression is upregulated in knockout mice that lack both VLDLR and ApoER2. Inversion of cortical layers and absence of cerebellar foliation in these animals precisely mimic the phenotype of mice lacking Reelin or mDab1. These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1.
展开
关键词：
Purkinje Cells Cerebral Cortex Dendrites Cell Line Animals Mice, Knockout Mice Mice, Mutant Strains Serine Endopeptidases Cell Adhesion Molecules, Neuronal
DOI：
10.1016/S0092-8674(00)80782-5
被引量：
年份：
1999
Elsevier
Elsevier
(全网免费下载)
万方医学
Semantic Scholar
(全网免费下载)
Semantic Scholar
查看更多
dx.doi.org
NCBI
Cell Press
NCBI
Cell Press
(全网免费下载)
Oxford Univ Press
Europe PMC
Cell Press
(全网免费下载)
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
teaching.herzlab.org
(全网免费下载)
jax.herzlab.org
(全网免费下载)
emboj.embopress.org
jlr.org
mcponline.org
d.scholar.cnki.net
core.ac.uk
(全网免费下载)
scienceopen.com
science-open.com
mendeley.com
ukpmc.ac.uk
gastrojournal.org
jacionline.org
atvb.ahajournals.org
molbiolcell.org
cghjournal.org
web.mit.edu
(全网免费下载)
ajprenal.physiology.org
web.mit.edu
(全网免费下载)
pubget.com
edoc.mdc-berlin.de
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
Cell Press
(全网免费下载)
Cell Press
(全网免费下载)
ResearchGate
(全网免费下载)
jax.herzlab.org
(全网免费下载)
core.ac.uk
(全网免费下载)
teaching.herzlab.org
(全网免费下载)
web.mit.edu
(全网免费下载)
web.mit.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
