Crystal Structure of the Tyrosine Phosphatase SHP-2

The structure of the SHP-2 tyrosine phosphatase, determined at 2.0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domai...

P Hof，S Pluskey，S Dhe-Paganon，... - 《Cell》

The structure and mechanism of protein phosphatases: insights into catalysis and regulation.

Eukaryotic protein phosphatases are structurally and functionally diverse enzymes that are represented by three distinct gene families. Two of these, the P...

D Barford，AK Das，MP Egloff - 《Annu Rev Biophys Biomol Struct》

THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation.

Eukaryotic protein phosphatases are structurally and functionally diverse enzymes that are represented by three distinct gene families. Two of these, the P...

Barford，David，Das，... - 《Annual Review of Biophysics & Biomolecular Structure》

Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity

Here, we present data suggesting a novel mechanism for regulation of natural killer (NK) cell cytotoxicity through inhibitory receptors. Interaction of act...

CC Stebbins，C Watzl，DD Billadeau，... - 《Molecular & Cellular Biology》

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction

Insulin signaling involves a dynamic cascade of protein tyrosine phosphorylation and dephosphorylation. Most of our understanding of this process comes fro...

JCH Byon，AB Kusari，J Kusari - 《Molecular & Cellular Biochemistry》

Protein tyrosine phosphatases–from housekeeping enzymes to master regulators of signal transduction

There are many misconceptions surrounding the roles of protein phosphatases in the regulation of signal transduction, perhaps the most damaging of which is...

NK Tonks - 《Febs Journal》

PTP1B: a double agent in metabolism and oncogenesis

PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received re...

SC Yip，S Saha，J Chernoff - 《Trends in Biochemical Sciences》

PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase.

We have investigated proteins which interact with the PEST-type protein tyrosine phosphatase, PTP hematopoietic stem cell fraction (HSCF), using the yeast ...

Spencer，S. - 《Journal of Cell Biology》

Protein Tyrosine Phosphatase 1B Antagonizes Signalling by Oncoprotein Tyrosine Kinase p210 bcr-abl In Vivo

The p210 bcr-abl protein tyrosine kinase (PTK) appears to be directly responsible for the initial manifestations of chronic myelogenous leukemia (CML). In ...

KR Lamontagne，AJ Flint，BR Franza，... - 《Molecular & Cellular Biology》

Protein tyrosine phosphatases: structure-function relationships.

Structural analysis of protein tyrosine phosphatases (PTPs) has expanded considerably in the last several years, producing more than 200 structures in this...

L Tabernero，AR Aricescu，EY Jones，... - 《Febs Journal》