Hot Water-Promoted Ring-Opening of Epoxides and Aziridines by Water and Other Nucleopliles
摘要:
Effective hydrolysis of epoxides and aziridines was conducted by heating them in water at 60 or 100 °C. Other types of nucleophile such as amines, sodium azide, and thiophenol could also efficiently open epoxides and aziridines in hot water. It was proposed that hot water acted as a modest acid catalyst, reactant, and solvent in the hydrolysis reactions.
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DOI:
10.1021/jo702401t
被引量:
年份:
2008
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