The history of Toll-like receptors - redefining innate immunity.
摘要：
The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, who, together with Ralph Steinman, the third winner of the 2011 Nobel Prize and the person who discovered the dendritic cell, were pioneers in the field of innate immunity. TLRs have a central role in immunity - in this Timeline article, we describe the landmark findings that gave rise to this important field of research.
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关键词：
Animals Humans Mitogen-Activated Protein Kinases NF-kappa B Protein Isoforms Transcription Factor AP-1 Inflammation Mediators Cytokines Signal Transduction Models, Immunological
DOI：
10.1038/nri3446
被引量：
年份：
2013
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