5-Lipoxygenase inhibitors isolated from gardeniae fructus.

来自 NCBI

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作者：

M Nishizawa，R Izuhara，K Kaneko，Y Koshihara，Y Fujimoto

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摘要：

Five 5-lipoxygenase inhibitors, chlorogenic acid (1), 6''-p-coumaroyl genipin gentiobioside (2), 3, 4-di-O-caffeoylquinic acid (3), 3-O-caffeoyl-4-O-sinapoylquinic acid (4) and 3, 5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid (5), were isolated from Gardeniae Fructus. The structures of the new compounds (2, 4 and 5) were elucidated on the basis of spectral data and chemical evidence. These hydroxycinnamic acid derivatives inhibit 5-lipoxygenase activity, and 3 was the most potent inhibitor. The inhibitory effects were enhanced on methylation of the carboxyl group(s) of 1, 3, 4 and 5, and the ID values of the methyl esters of 3, 4 and 5 were of the order of 10M.

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关键词：

Gardeniae Fructus Gardenia jasminoides Rubiaceae lipoxygenase inhibitor chlorogenic acid 6''-O-p-coumaroyl genipin gentiobioside 3, 4-di-O-caffeoylquinic acid 3-O-caffeoyl-4-O-sinapoylquinic acid 3, 5-di-O-caffeoyl-4-O-(3-hydroxy-3-methyl)glutaroylquinic acid long-range selective proton decoupling (LSPD