Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities.

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作者：

Takeshi，Yamada，Masashi，Iritani，Hirohumi，Ohishi，Kayo，Tanaka，Katsuhiko，Minoura

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摘要：

Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1-3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound inhibited the protein kinase EGFR and topoisomerase II.

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关键词：

Providencia alcalifaciens Lipopolysaccharide O-Antigen Bacterial polysaccharide structure 2,4-Dihydroxypentanoic acid

DOI：

10.1039/b713060k

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年份：

2007