Differential Requirements for Survival and Proliferation of CD8 Nave or Memory T Cells

来自 Semantic Scholar

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109

作者：

C Tanchot，FA Lemonnier，B Perarnau，AA Freitas，B Rocha

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摘要：

The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8$^+$ T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.

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关键词：

Adoptive Transfer Animals CD8-Positive T-Lymphocytes cytology immunology transplantation Cell Division Cell Survival Comparative Study Female H-2 Antigens immunology H-Y Antigen immunology Immunologic Memory Lymphocyte Activation Male Mice Mice Inbred C57BL Mice Transgenic Receptors Antigen T-Cell alpha-beta immunology Research Support Non-U.S. Gov't T-Lymphocyte Subsets cytology immunology transplantation