Malaria parasite proteins that remodel the host erythrocyte
摘要：
Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the erythrocyte membrane and induce substantial changes in the morphology, physiology and function of the host cell. These changes underlie the pathology that is responsible for the deaths of 1-2 million children every year due to malaria infections. The advent of molecular transfection technology, including the ability to generate deletion mutants and to introduce fluorescent reporter proteins that track the locations and dynamics of parasite proteins, has increased our understanding of the processes and machinery for export of proteins in P. falciparum-infected erythrocytes and has provided us with insights into the functions of the parasite protein exportome. We review these developments, focusing on parasite proteins that interact with the erythrocyte membrane skeleton or that promote delivery of the major virulence protein, PfEMP1, to the erythrocyte membrane.
展开
关键词：
FALCIPARUM-INFECTED ERYTHROCYTES RED-BLOOD-CELLS HISTIDINE-RICH PROTEIN PARASITOPHOROUS VACUOLE MEMBRANE VESICLE-MEDIATED TRAFFICKING MAURERS CLEFT ORGANELLES RING-EXPORTED PROTEIN-1 PLASMODIUM-FALCIPARUM SURFACE-ANTIGEN BINDING DOMAIN
DOI：
10.1002/bit.10848
被引量：
年份：
2009
Nature
Nature
(全网免费下载)
Springer
国家科技图书文献中心
(权威机构)
Wiley
查看更多
万方医学
Semantic Scholar
dx.doi.org
Ingenta
NCBI
CAB Direct
Europe PMC
NCBI
ProQuest
ResearchGate
EBSCO
EBSCO
EBSCO
deepdyve.com
hdl.handle.net
en.zl50.com
go.galegroup.com
ec.asm.org
arrow.latrobe.edu.au:8080
ftp.palgrave-journals.com
readcube.com
mcponline.org
core.ac.uk
science-open.com
base-search.net
digitalcollections.anu.edu.au
arrow.monash.edu.au
bvsalud.org
scienceopen.com
mendeley.com
jacionline.org
onAcademic
www.socolar.com
学术范
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
