Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
摘要：
Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. The C-terminal half of the juxtamembrane segment latches the activated kinase domain to the activator, and the N-terminal half of this segment further potentiates dimerization, most likely by forming an antiparallel helical dimer that engages the transmembrane helices of the activated receptor. Our data are consistent with a mechanism in which the extracellular domains block the intrinsic ability of the transmembrane and cytoplasmic domains to dimerize and activate, with ligand binding releasing this block. The formation of the activating juxtamembrane latch is prevented by the C-terminal tails in a structure of an inactive kinase domain dimer, suggesting how alternative dimers can prevent ligand-independent activation.
展开
DOI：
10.1016/j.cell.2009.04.025
被引量：
年份：
2009
Elsevier
(全网免费下载)
Elsevier
国家科技图书文献中心
(权威机构)
Semantic Scholar
(全网免费下载)
掌桥科研
查看更多
Semantic Scholar
万方医学
Ingenta
dx.doi.org
BioMed Central
Europe PMC
(全网免费下载)
www.cell.com
Europe PMC
NCBI
Cell Press
(全网免费下载)
BioMed Central
Cell Press
(全网免费下载)
NCBI
(全网免费下载)
NCBI
ResearchGate
EBSCO
Citeseer
(全网免费下载)
pubget.com
infona.pl
utsouthwestern.influuent.utsystem.edu
bms.ucsf.edu
(全网免费下载)
pubfacts.com
bvsalud.org
scienceopen.com
f1000.com
mcr.aacrjournals.org
rstb.royalsocietypublishing.org
physiologyonline.physiology.org
molbiolcell.org
jcs.biologists.org
rcsb.org
readcube.com
mendeley.com
pdb.org
core.ac.uk
(全网免费下载)
onAcademic
学术范
学术范
(全网免费下载)
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Cell Press
(全网免费下载)
Cell Press
(全网免费下载)
Citeseer
(全网免费下载)
bms.ucsf.edu
(全网免费下载)
学术范
(全网免费下载)
core.ac.uk
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
