摘要：

6(R)-[2-(8'-Etherified-hydroxy-2',6'- dimethyl- polyhydronaphthyl-1') -ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection of the 4(R)-hydroxyl and the 2-keto group, followed by reductive removal of the 8'-acyloxy group, etherification of the resulting 8'-hydroxyl and removal of the protecting groups. The corresponding hydroxy acids and the salts and lower alkyl esters of said hydroxy acids and their preparation are also disclosed. The procucts inhibit the biosynthesis of cholesterol.

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