The TGF-?? signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that frequently metastasizes and that overexpresses transforming growth factor-beta s (TGF-beta s). To determine whether TGF-beta s can act to enhance the metastatic potential of PDAC, PANC-1 human pancreatic cancer cells were transfected with an expression construct encoding a soluble type II TGF-beta receptor (sT beta RII) that...
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DOI：
10.1038/sj.onc.1202909
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年份：
1999
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来源期刊
Oncogene
1999/10/01
引用走势
2004
被引量：58
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