Mepolizumab and exacerbations of refractory eosinophilic asthma.
阅读量：
494
摘要：
The article reports on research which attempted to determine if eosinophilic inflammation of the airway is associated with the risk of exacerbations of asthma. Researchers conducted a randomized, double-blind, placebo-controlled, parallel-group study of 61 subjects who had refractory eosinophilic asthma and a history of recurrent severe exacerbations. They found that mepolizumab was associated with significantly fewer severe exacerbations than placebo over the course of 50 weeks and that mepolizumab significantly lowered eosinophil counts in the blood (P<0.001) and sputum (P=0.002). They concluded that mepolizumab therapy reduces exacerbations and improves AQLQ scores in patients with refractory eosinophilic asthma.and that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in the patient population that they studied.
展开
关键词：
Eosinophils Sputum Humans Asthma Eosinophilia Recurrence Prednisolone Biological Markers Interleukin-5 Antibodies, Monoclonal
DOI：
10.1056/NEJMoa0808991
被引量：
年份：
2009
Taylor & Francis
BMJ
掌桥科研
万方医学
Europe PMC
查看更多
NCBI
(全网免费下载)
Oxford Univ Press
Europe PMC
(全网免费下载)
NCBI
The Lancet
ProQuest
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
EBSCO
EBSCO
mendeley.com
gastrojournal.org
cmaj.ca
files.medicinaufac.com
(全网免费下载)
nejm.org
(全网免费下载)
core.ac.uk
lra.le.ac.uk
jacionline.org
nejm.org
progettolibra.it
(全网免费下载)
www.socolar.com
bvsalud.org
jem.rupress.org
hdl.handle.net
ora.ox.ac.uk
d.scholar.cnki.net
scienceopen.com
emboj.embopress.org
birpublications.org
199.107.238.205
openres.ersjournals.com
science-open.com
onAcademic
pubfacts.com
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
files.medicinaufac.com
(全网免费下载)
nejm.org
(全网免费下载)
progettolibra.it
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
