Heat-shock proteins induce T-cell regulation of chronic inflammation.

来自 EBSCO

阅读量:

168

作者:

W Van EdenVDZ RuurdB Prakken

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摘要:

Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.

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DOI:

10.1038/nri1593

被引量:

1036

年份:

2005

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2012
被引量:121

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