Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity
摘要：
Several derivatives containing dihydronaphtho, naphtho[2,1- b]thiophene and thieno[2,3- d]pyrimidine ring systems were prepared starting from 2-amino-4,5-dihydronaphtho[2,1- b]thiophene-1-carbonitrile ( 1). Structure characterization of the thioxo derivative 7 was also performed and its reaction with some chloro and bromoalkyl reagents was studied. Moreover, the prepared products were tested for antiviral activity against H5N1 virus [A/chicken/Egypt/1/2006 (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on MDCK cells. Compounds 5, 7 and 8 showed the highest effect compared with the other tested compounds.
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关键词：
Dihydronaphtho[2,1- b]thiophene Naphtho[2,1- b]thiophene Thieno[2,3- d]pyrimidine S-alkyl derivatives Anti-avian influenza virus (H5N1
DOI：
10.1016/j.ejmech.2010.08.044
被引量：
年份：
2010
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