Induction of Pulmonary Tumours in Mice by Nitrosonornicotine, a Possible Constituent of Tobacco Smoke

来自 EBSCO

阅读量:

41

作者:

E BoylandFJC RoeJW Gorrod

展开

摘要:

NITROSAMINES could be formed in cigarette smoke by reactions between secondary amines and oxides of nitrogen 1,2 . Several secondary amines, including anabasine, nornicotine, dimethylamine, diethylamine, pyrrolidine, piperidine and proline, have been detected in cigarette smoke, which also contains about 200 parts per million of oxides of nitrogen (as the sum of NO and NO 2 ) (refs. 3 and 4). The nitrosamine derivatives of some of these amines have already been shown to be carcinogenic 5,6 . We have reported that nitrosoanabasine administered in the drinking water induced benign and malignant tumours of the sophagus of rats 1 . In parallel with these biological investigations, attempts have been made to detect nitrosoanabasine and nitrosonornicotine in cigarette smoke. So far these attempts have not been successful, although methods capable of detecting small amounts (for example, 5 g) of specific nitrosamines have been developed 1 . Lack of success may be due either to instability of nitrosamines under the conditions prevailing in cigarette smoke or to interference in their detection by other constituents of the smoke. Nitrosoanabasine could not be detected in cigarette smoke condensates to which it had been deliberately added nor in the smoke of cigarettes which had been impregnated with the substance before smoking. If these negative results are due to instability of the nitrosamines, the possibility of their biological importance is only ruled out if their half-lives are very short. Further investigations into these problems are in progress.

展开

DOI:

10.1038/2021126a0

被引量:

109

年份:

1964

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

引用走势

1975
被引量:8

站内活动

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

关于我们

百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。
了解更多>>

友情链接

百度云百度翻译

联系我们

合作与服务

期刊合作 图书馆合作 下载产品手册

©2025 Baidu 百度学术声明 使用百度前必读

引用