The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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115

作者：

A Veillette，MA Bookman，EM Horak，JB Bolen

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摘要：

The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation. We report our evaluation of the possible involvement of the lymphocyte-specific tyrosine kinase p56 lck in these transduction pathways. Our data demonstrate that p56 lck is specifically modulated with either CD4 or CD8 following antibody-mediated cross-linking of these molecules and that a large fraction of the total cellular lck protein can be coimmunoprecipitated with these surface glycoproteins. These results suggest that p56 lck is functionally and physically associated with CD4 CD8 in normal murine T lymphocytes and support the concept that an independent signal is transduced by the interaction of these surface molecules with major histocompatibility complex determinants.

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关键词：

T-Lymphocytes Cell Line Animals Mice Antigens, Differentiation, T-Lymphocyte Signal Transduction Major Histocompatibility Complex Protein-Tyrosine Kinases