Targeting the endocannabinoid system: to enhance or reduce?
摘要：
As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in tissues change, and their effects vary from those of protective endogenous compounds to those of dysregulated signals. These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases. When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment.
展开
关键词：
Animals Humans Gastrointestinal Diseases Neurodegenerative Diseases Metabolic Diseases Endocannabinoids Cannabinoids Central Nervous System Diseases Models, Biological Cannabinoid Receptor Modulators
DOI：
10.1038/nrd2553
被引量：
Taylor & Francis
Springer
Nature
(全网免费下载)
Nature
国家科技图书文献中心
(权威机构)
查看更多
EBSCO
掌桥科研
doi.org
万方医学
Semantic Scholar
dx.doi.org
Ingenta
NCBI
Oxford Univ Press
NCBI
Europe PMC
ProQuest
ResearchGate
EBSCO
go.galegroup.com
pharmrev.aspetjournals.org
mendeley.com
jlr.org
rstb.royalsocietypublishing.org
bprcem.com
readcube.com
deepdyve.com
ftp.palgrave-journals.com
onAcademic
xa.yimg.com
(全网免费下载)
www.socolar.com
Nature
(全网免费下载)
xa.yimg.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
