Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens
摘要：
The hope that hybridoma antibodies would reveal unique cell surface antigens during embryogenesis, differentiation and oncogenesis has been replaced by the realization that such antigens are mainly carbohydrate structures of glycoproteins and glycolipids occurring in many cell types. These findings either may reflect limitations in the methods of selection of hybridoma antibodies or may point to important roles for the diverse carbohydrate structures as receptors for regulators of cell growth and differentiation.
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关键词：
Humans Carbohydrates Glycolipids Glycoproteins Antibodies, Monoclonal Antigens, Neoplasm Blood Group Antigens Epitopes Cell Division Cell Differentiation
DOI：
10.1038/314053a0
被引量：
年份：
1985
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