B-cell memory is short-lived in the absence of antigen.
摘要：
Primary encounter with antigen stimulates specific B cells not only to differentiate into cells that produce antibody at a high rate (plasma cells), but also to give rise to populations of memory cells. These cells have many characteristics that differ from virgin B cells, including their lifespan 1 . When re-exposed to antigen, memory cells generate secondary IgG responses that are enhanced in rate, titre and affinity. At present they are considered as small resting lymphocytes which survive for long periods in a quiescent state between each antigen encounter 2 . However, the fact that an individual may continue to make an antibody response for many months following a single injection of antigen 3,4 is often overlooked. This continued antibody production is probably due to repeated stimulation of antigen-specific B cells and raises the question of whether memory B-cell clones require antigen for their maintenance. Here we show that they do and that following transfer, in the absence of antigen, memory B-cell populations are lost from the adoptive host after 10–12 weeks.
展开
DOI：
10.1038/336070a0
被引量：
年份：
1988
Nature
(全网免费下载)
Springer
Nature
EBSCO
Wiley
查看更多
万方医学
Semantic Scholar
dx.doi.org
Europe PMC
(全网免费下载)
Oxford Univ Press
NCBI
(全网免费下载)
NCBI
Europe PMC
NCBI
AACR
adsabs.harvard.edu
ResearchGate
ProQuest
Citeseer
(全网免费下载)
Citeseer
EBSCO
core.ac.uk
mysciencework.com
cvi.asm.org
199.171.202.195
deepdyve.com
jem.rupress.org
emboj.embopress.org
jacionline.org
jimmunol.org
fasebj.org
gastrojournal.org
jem.rupress.org
(全网免费下载)
onAcademic
mendeley.com
readcube.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
