摘要：

Objective To study the anti-angiogenic activity of extract from Winged Euonymus Twig.Methods Human umbilical vein endothelial cells(HUVEC) model,rat aortic ring model and chicken chorioallantoic membrane(CAM) model were used to evaluate the anti-angiogenesis effect of extract from Ramulus Euonymi respectively.Results Extract from Winged Euonymus Twig inhibited the proliferation of HUVEC with inhibition ratio of 36.2% at 8 μg·mL-1.Extract from Winged Euonymus Twig could inhibit the neovascularization of rat aortic rings with inhibition ratio of 56.41% and 65.25% at 2 and 4 μg·mL-1.In the chicken CAM experiment,extract from Winged Euonymus Twig induced 22.6% and 31.2% inhibition ratio of microvessel density at 20 and 40 μg·egg-1,respectively.Conclusion Extract from Winged Euonymus Twig showes significant anti-angiogenic activities.

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