Synthesis of congeners of migrastatin and dorrigocin A from d-xylose
摘要：
Migrastatin and dorrigocin A analogues have potential as anti-metastatic agents that act by targeting the actin-bundling protein, fascin. Syntheses of close structural analogues of these agents have been achieved. Wittig and Ando olefination reactions with an aldehyde obtained from d-xylose, respectively, gave two trisubstituted alkene intermediates that were then elaborated into either macrolactone or macrolactam analogues of migrastatin or to an acyclic dorrigocin A analogue.
展开
关键词：
Aldehydes Ammonium acetate 1,2-Dicarbonyl compounds DABCO Multi-component Condensation Imidazoles Aromatic amines
DOI：
10.1016/j.tetlet.2010.07.141
被引量：
年份：
2010
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
