Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases
摘要：
The complement and immunoglobulin receptors are the major phagocytic receptors involved during infection. However, only immunoglobulin-dependent uptake results in a respiratory burst and an inflammatory response in macrophages. Rho guanosine triphosphatases (molecular switches that control the organization of the actin cytoskeleton) were found to be essential for both types of phagocytosis. Two distinct mechanisms of phagocytosis were identified: Type I, used by the immunoglobulin receptor, is mediated by Cdc42 and Rac, and type II, used by the complement receptor, is mediated by Rho. These results suggest a molecular basis for the different biological consequences that are associated with phagocytosis.
展开
关键词：
Antigens CD GTP Phosphohydrolases metabolism Macrophage-1 Antigen Phagocytosis 抗原 CD 巨噬细胞1抗原 吞噬作用 受体 IGG
DOI：
10.1126/science.282.5394.1717
被引量：
年份：
1998
BMJ
掌桥科研
Semantic Scholar
Semantic Scholar
(全网免费下载)
万方医学
查看更多
dx.doi.org
Europe PMC
Oxford Univ Press
JSTOR
Cell Press
NCBI
NCBI
JBC
dialnet.unirioja.es
adsabs.harvard.edu
ResearchGate
ProQuest
EBSCO
Citeseer
(全网免费下载)
EBSCO
readcube.com
jasn.asnjournals.org
ressources.unisciel.fr
(全网免费下载)
www.socolar.com
bloodjournal.org
cheric.org
elifesciences.org
science.org
biochemj.org
highbeam.com
emboj.embopress.org
sciencemag.org
jcb.rupress.org
ulysse.u-bordeaux.fr
(全网免费下载)
onacademic.com
mendeley.com
mct.aacrjournals.org
cmr.asm.org
cghjournal.org
intl-physiologyonline.physiology.org
fasebj.org
jimmunol.org
genesdev.cshlp.org
molbiolcell.org
respiratory-research.com
jcs.biologists.org
scienceopen.com
ganino.com
(全网免费下载)
baywood.metapress.com
Semantic Scholar
(全网免费下载)
Citeseer
(全网免费下载)
ulysse.u-bordeaux.fr
(全网免费下载)
ressources.unisciel.fr
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
