摘要：

The invention relates to rapidly dissolving granules obtainable by preparing an aqueous granulating liquid containing at least one binder; spraying the granulating liquid obtained in step (a) in a fluidized bed by the counter-flow method at a constant air supply temperature on to a carrier containing at least one carbohydrate, wherein bromhexin/bromhexinhydrochloride and citric acid are used independently of one another in the granulating liquid and/or carrier. For the first time the teaching according to the invention provides a water soluble granulated preparation which contains bromhexin/bromhexinhydrochloride as active substance. These granules according to the invention are water soluble in spite of the fact that bromhexin/bromhexinhydrochloride per se is almost insoluble in water, i.e., the granules are fully dissolved in water within a few minutes and release the active substance in its entirety.

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