Regulation of Proopiomelanocortin Gene Expression

来自 EBSCO

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摘要：

Pituitary melanotroph and corticotroph cells produce and secrete peptides from the multifunctional precursor protein proopiomelanocortin (POMC). Stimulation of the secretory activity of both cell types involves production of cyclic 3′5′-adenosine monophosphate (cAMP) and increases in the concentration of intracellular Ca2+. The increase in secretory activity is accompanied by enhanced expression of the POMC gene. Surprisingly, the POMC promoter lacks both cAMP-responsive elements and Ca2+-responsive elements through which the cAMP and Ca2+ signals could, in a relatively direct way, act on POMC gene expression. It is thus apparent that other, more indirect, mechanisms have evolved to utilize cAMP and Ca2+ signaling cascades to regulate POMC expression. This review gives an overview of the complex pathways and events that lead to the regulation of POMC gene expression in corticotrophs and melanotrophs. Another major site for POMC pr

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关键词：

proopiomelanocortin gene expression responsive elements transcription factors corticotroph melanotroph ACTH MSH Nur 77 Nur factors