摘要：

Objective To study the effects of atorvastatin on the expressions of peroxisome proliferators-activated receptor gamma(PPARγ)and matrix metalloproteinase-9(MMP-9)in atherosclerosis(AS) tissue.Methods Atherosclerotic rabbit models on aortas were established with the high-cholesterol diet,and animals were divided into control,model and atorvastatin groups(n=8).The expressions of PPARγ and MMP-9 and the effects of atorvastatin on them were observed by means of immunohistochemistry.Results The expression of PPARγ in model group(14.38%±2.58%)was higher than that in control group(7.82%±0.96%)(P0.01),and the expression of MMP-9 in model group(17.13%±1.58%)was also higher than that in control group(2.72%±0.36%)(P0.01).The expression of PPARγ in atorvastatin group(16.11%±2.35%)was higher than in model group(P0.01),and the expression of MMP-9 in atorvastatin group(12.11%±2.05%)was lower than that in model group(P0.01).Conclusion Atorvastatin can increase the expression of PPARγ and inhibit the expression of MMP-9.These results suggest that atorvastatin has anti-inflammatory effects which are probably related to its activating PPARγ and inhibiting MMP-9.

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