摘要：

Metal complexes of 2-pyridinecarboxaldehyde 2′-pyridylhydrazone (PCPH) and related compounds with manganese(II), iron(II), cobalt(II), nickel(Il), copper(II), zinc(II) and platinum(II) were synthesized and characterized by magnetic susceptibility measurements down to liquid nitrogen temperature and also by electronic, infrared, electron spin resonance and Mssbauer spectra. All the metal(II) complexes appeared to be monomeric, high-spin, five-coordinate (square-pyramidal) (X = Cl or OAc), except for Ni(PCPH)Cl2 which is polymeric, high-spin, six-coordinate. Each ligand behaved as a tridentate NNN donor, via the pyridine nitrogen, azomethine nitrogen, and pyridine or quinoline nitrogen. One of the most active agents of this series, Cu(PCPH)Cl2, showed antitumour activity against a variety of transplanted tumours, including Sarcoma 180, Ehrlich carcinoma and L1210 leukaemia sensitive to α(N)-heterocyclic carboxaldehyde thiosemicarbazones. This agent caused inhibition of 3H-thymidine and 3H-uridine incorporation into DNA and RNA, respectively, of Sarcoma 180 ascites cells; protein biosynthesis was relatively insensitive to the action of this agent.

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