摘要：

three pdii complexes were prepared from n(4)-substituted thiosemicarbazones: [pd(aptsc)(pph3)](no3)?h2o, 1, [pd(apmtsc)(pph3)](no3), 2, and [pd(apptsc)(pph3)](no3)?h2o, 3, where pph3 = triphenylphosphine; haptsc = 2-acetylpyridine-thiosemicarbazone; hapmtsc = 2-acetylpyridine-n(4)-methyl-thiosemicarbazone and happtsc = 2-acetylpyridine-n(4)-phenyl-thiosemicarbazone. all complexes were characterized by elemental analysis, ir, uv-vis, 1h and 31p{1h} nmr spectroscopies, and had their crystalline structures determined by x-ray diffractometry from single crystals. the monoanionic thiosemicarbazonate ligands act in a tridentate mode, binding to the metal through the pyridine nitrogen, the azomethine nitrogen and the sulfur atoms. the cytotoxic activity against the breast cancer cell line mda-mb231 and the anti-mycobacterium tuberculosis h37rv atcc 27294 activity were evaluated for the compounds. all pdii complexes were highly active against the studied cell line, presenting similar values of ic50, around 5 μmol l-1, while the clinically applied antitumor agent cisplatin was inactive. the compounds show remarkable anti-m. tuberculosis activities, presenting mic values comparable or better than some commercial anti-m tuberculosis drugs.

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