To kill a tumor cell: the potential of proapoptotic receptor agonists
摘要：
Disturbances in mechanisms that direct abnormal cells to undergo apoptosis frequently and critically contribute to tumorigenesis, yielding a logical target for potential therapeutic intervention. There is currently heightened interest in the extrinsic apoptosis pathway, with several proapoptotic receptor agonists (PARAs) in development. The PARAs include the ligand recombinant human Apo2L/TRAIL and agonistic mAbs. Mechanistic and preclinical data with Apo2L/TRAIL indicate exciting opportunities for synergy with conventional therapies and for combining PARAs with other molecularly targeted agents. Novel molecular biomarkers may help identify those patients most likely to benefit from PARA therapy.
展开
关键词：
Animals Humans Mitochondria DNA Recombinant Proteins Proto-Oncogene Proteins c-bcl-2 Tumor Markers, Biological Antibodies, Monoclonal Apoptosis Receptors, Death Domain
DOI：
10.1172/JCI34359
被引量：
年份：
2008
国家科技图书文献中心
(权威机构)
Wiley
万方医学
掌桥科研
Semantic Scholar
(全网免费下载)
查看更多
dx.doi.org
NCBI
Europe PMC
(全网免费下载)
Oxford Univ Press
Europe PMC
Pubmed Central
(全网免费下载)
NCBI
(全网免费下载)
NCBI
ResearchGate
(全网免费下载)
ProQuest
EBSCO
jvi.asm.org
core.ac.uk
ajprenal.physiology.org
jci.org
(全网免费下载)
erc.endocrinology-journals.org
molbiolcell.org
学术范
readcube.com
dm5migu4zj3pb.cloudfront.net
(全网免费下载)
ar.iiarjournals.org
学术范
(全网免费下载)
core.kmi.open.ac.uk
science-open.com
highbeam.com
pubfacts.com
bloodjournal.org
fasebj.org
jimmunol.org
mct.aacrjournals.org
jnm.snmjournals.org
static.jci.org
(全网免费下载)
gastrojournal.org
jci.org
emboj.embopress.org
Semantic Scholar
(全网免费下载)
Pubmed Central
(全网免费下载)
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
dm5migu4zj3pb.cloudfront.net
(全网免费下载)
jci.org
(全网免费下载)
学术范
(全网免费下载)
static.jci.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
