THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulatio...

AS Baldwin - 《Annual Review of Immunology》

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.

A link between inflammation and cancer has long been suspected, but its molecular nature remained ill defined. A key player in inflammation is transcriptio...

FR Greten，L Eckmann，TF Greten，... - 《Cell》

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.

Patients with familial adenomatous polyposis have a nearly 100 percent risk of colorectal cancer. In this disease, the chemopreventive effects of nonsteroi...

G Steinbach，PM Lynch，RKS Phillips，... - 《New England Journal of Medicine》

Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cy...

MJ Thun，SJ Henley，C Patrono - 《J Natl Cancer Inst》

Beg, A.A. & Baltimore, D. An essential role for NF-B in preventing TNF-induced cell death. Science 274, 782-784

Studies on mice deficient in nuclear factor kappa B (NF-kappaB) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) su...

A Beg，David Baltimore - 《Science》

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic act...

RA Gupta，RN Dubois - 《Nature Reviews Cancer》

Cyclooxygenase-independent actions of cyclooxygenase inhibitors

Several studies have demonstrated unequivocally that certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, ...

I Tegeder，J Pfeilschifter，G Geisslinger - 《Faseb Journal》

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Skeletal muscle has recently been identified as an endocrine organ. It has, therefore, been suggested that cytokines and other peptides that are produced, ...

BK Pedersen，MA Febbraio - 《Physiological Reviews》

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

Activation of the transcription factor nuclear factor (NF)-κB by proinflammatory stimuli leads to increased expression of genes involved in inflammation. ...

MJ May，F D'Acquisto，LA Madge，... - 《Science》

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.

Activation of the transcription factor nuclear factor (NF)-kappaB by proinflammatory stimuli leads to increased expression of genes involved in inflammatio...

May，M. J - 《Science》