A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.

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作者：

WW He，PJ Sciavolino，J Wing，M Augustus，P Hudson，PS Meissner，RT Curtis，BK Shell，DG Bostwick，DJ Tindall

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摘要：

We have isolated a prostate-specific gene ( NKX3.1 ) in humans that is homologous to the Drosophila NK homeobox gene family. Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testis, but is expressed little or not at all in several other tissues. In an androgen-dependent prostate carcinoma line, LNCaP, NKX3.1 mRNA is expressed at a basal level that was increased markedly upon androgen stimulation; the NKX3.1 mRNA was undetectable in several other human tumor cell lines including two androgen-independent prostate carcinoma lines. The NKX3.1 gene maps to chromosome band 8p21, a region frequently reported to undergo a loss of heterozygosity associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer. Based on these data we propose that NKX3.1 is a candidate gene for playing a role in the opposing processes of androgen-driven differentiation of prostatic tissue and loss of that differentiation during the progression of prostate cancer.

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关键词：

Animals Humans Mice Prostate Drosophila Tumor Cells, Cultured Chromosomes, Human, Pair 8 Prostatic Neoplasms Neoplasms, Hormone-Dependent Chromosome Deletion