Phosphine‐Catalyzed Asymmetric Formal [4+2]Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles
摘要：
The first highly enantioselective formal [4+2]tandem cyclizations between isatylidenemalononitriles and activated dienes catalyzed by bifunctional chiral phosphine catalysts have been developed, yielding multistereogenic spirocyclic oxindoles in high yields and excellent optical purity. This reaction is accomplished via a tandem RauhutCurrier/Michael/RauhutCurrier reaction sequence.
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关键词：
activated dienes asymmetric [4+2] cyclization chiral phosphines multistereogenic spirocyclic oxindoles organocascade reactions
DOI：
10.1002/adsc.201301070
被引量：
年份：
2014
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