Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone
摘要：
We reported the first example of organocatalytic Michael addition of unprotected 3-prochiral oxindoles b1/b to 1,4-naphthoquinone. Quinidine derivative (DHQD)sub2/subPYR was found to be able to catalyze this reaction in up to 83% ee, with moderate to excellent yields. This method could be used for the synthesis of enantioenriched 3,3-diaryloxindoles, and the catalytic synthesis of which was unprecedented.
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关键词：
3,3-disubstituted oxindoles Michael addition organocatalysis quaternary stereogenic center unprotected 3-substituted oxindoles
DOI：
10.3762/bjoc.8.157
被引量：
年份：
2012
Elsevier
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