Alternative synthetic route to chiral N-substituted camphor-derived beta-amino alcohols
摘要：
An alternative route from (1 R )-(+)-camphor to chiral N-substituted camphor-derived -amino alcohol ( 4b - e ) consists of four steps with a total yield of 28%. N-Alkylation of camphor-derived -amino alcohol ( 4a ) involves condensation and hydride reduction in one pot without isolation of intermediates. Condensation of 4a with aldehydes or ketones generates a mixture of 1,3-oxazolidines ( 6 ) and imino-alcohols ( 7 ), which are reduced to 4b - e by NaBH4. Chirality, 2007. 2007 Wiley-Liss, Inc.
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DOI：
10.1002/chir.20373
被引量：
年份：
2010
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