A new convenient four-component synthesis of 6-amino-2 H , 4 H -pyrano[2,3- c ]pyrazole-5-carbonitriles and one-pot synthesis of 6 ′-amino-5-cyano-1,2-dihydrospiro-[(3 H )-indole-3,4 ′-(4 ′ H )-pyrano[2,3- c ]pyrazol]-2-ones
摘要:
A new convenient method for the synthesis of 6-amino-2 H ,4 H -pyrano[2,3- c ]pyrazole-5-carbonitriles, namely, four-component condensation of carbonyl compounds (aromatic aldehydes, heterocyclic ketones), malononitrile, β-keto esters, and hydrazine hydrate in ethanol in the presence of triethylamine as a catalyst, which occurs selectively, is developed. One-pot two-step modification of this method is proposed for the synthesis of spiro[(3 H )-indole-3,4 ′-(4′ H )-pyrano[2,3- c ]pyrazol]-2-ones.
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关键词:
four-component reaction one-pot modification 6-amino-2H,4H-pyrano-[2,3-c]pyrazole-5-carbonitriles 2 ′-amino-5 ′-cyanospiro[(3H)-indole-3,4 ′-(4 ′H)-pyran]-2-ones aromatic aldehydes piperidin-4-ones isatins malononitrile β-keto esters hydrazine hydrate triethylamine
DOI:
10.1007/s11172-009-0328-4
被引量:
年份:
2009












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