Allergen‐induced increase in non‐allergic bronchial reactivity

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作者：

DW Cockcroft，RE Ruffin，J Dolovich，FE Hargreave

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摘要：

Non-allergic bronchial hyper-reactivity is a feature of most patients with asthma. We have measured non-allergic bronchial reactivity to inhaled histamine and methacholine in thirteen asthmatic subjects before and after allergen inhalation in the laboratory. The allergen inhalation produced mild early asthmatic responses (1940% FEV 1 fall) in all thirteen, additional definite late asthmatic responses (1729% FEV 1 fall) in four, and equivocal late asthmatic responses (511% FEV 1 fall) in five. Following allergen inhalation, non-allergic bronchial reactivity increased in seven for up to 7 days. The seven included all four with definite late asthmatic responses and three of the five with equivocal late asthmatic responses. We conclude that allergens make asthma worse, partly through non-allergic mechanisms, and that avoidance of allergens is important in reducing non-allergic bronchial hyper-reactivity.

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关键词：

ALLERGENS ANTIGENS ASTHMA BRONCHI -- Diseases HISTAMINE

DOI：

10.1111/j.1365-2222.1977.tb01481.x

被引量：

6145

年份：

1977