An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA
摘要：
MITOCHONDRIAL DNA (mtDNA) contains genes for the ribosomal RNAs (rRNAs) and transfer RNAs (tRNAs) used in mitochondrial protein synthesis and for a limited number of proteins of the mitochondrial inner membrane 1–4 . By a combination of genetic and physical mapping, the location of most of these genes on yeast mtDNA has been determined 3,4 . There is a single gene for the RNA from the large subunit of yeast mitochondrial ribosomes 5 , but, nevertheless, this RNA hybridises to non-adjacent fragments on the physical map of mtDNA 6 . Although this suggested that the gene for this RNA is split, like some eukaryotic nuclear genes 7 , the presence of partial gene duplications complicated the interpretation of our hybridisation experiments 6 . By electron microscopy of RNA–DNA hybrids we now present direct evidence for an insertion in this rRNA gene.
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DOI：
10.1038/275336a0
被引量：
年份：
1978
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