摘要：

Presents research which showed that protein kinase B phosphorylates AFX, a human orthologue of Forkhead transcription factor daf-16. Role of protein kinase B in the regulation of insulin-responsive genes; Genetic analysis of Caenorhabditis elegans; Effects of the inhibition of endogenous PI(3)K and protein kinase B activity; Delineation of a pathway for PI(3)K-dependent signaling.

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