Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.
摘要：
The venom of the black mamba contains a 60-amino acid peptide called calciseptine. The peptide has been fully sequenced. It is a smooth muscle relaxant and an inhibitor of cardiac contractions. Its physiological action resembles that of drugs, such as the 1,4-dihydropyridines, which are important in the treatment of cardiovascular diseases. Calciseptine, like the 1,4-dihydropyridines, selectively blocks L-type Ca2+channels and is totally inactive on other voltage-dependent Ca2+channels such as N-type and T-type channels. To our knowledge, it is the only natural polypeptide that has been shown to be a specific inhibitor of L-type Ca2+channels.
展开
DOI：
10.1073/pnas.88.6.2437
被引量：
年份：
1991
掌桥科研
万方医学
dx.doi.org
Europe PMC
(全网免费下载)
JSTOR
查看更多
NCBI
NCBI
(全网免费下载)
Oxford Univ Press
NCBI
Europe PMC
JBC
NRC Research Press
adsabs.harvard.edu
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
plantphysiol.org
pnas.org
(全网免费下载)
ajpcell.physiology.org
onAcademic
molpharm.aspetjournals.org
mysciencework.com
The National Academy of Sciences of the United States of America
(全网免费下载)
readcube.com
core.ac.uk
hyper.ahajournals.org
pherobase.com
mendeley.com
pnas.org
scripts.iucr.org
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
The National Academy of Sciences of the United States of America
(全网免费下载)
pnas.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
研究点推荐
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
