Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.

来自 NCBI

阅读量:

43

作者:

de Weille, J. RH SchweitzP MaesA TartarM Lazdunski

展开

摘要:

The venom of the black mamba contains a 60-amino acid peptide called calciseptine. The peptide has been fully sequenced. It is a smooth muscle relaxant and an inhibitor of cardiac contractions. Its physiological action resembles that of drugs, such as the 1,4-dihydropyridines, which are important in the treatment of cardiovascular diseases. Calciseptine, like the 1,4-dihydropyridines, selectively blocks L-type Ca2+channels and is totally inactive on other voltage-dependent Ca2+channels such as N-type and T-type channels. To our knowledge, it is the only natural polypeptide that has been shown to be a specific inhibitor of L-type Ca2+channels.

展开

DOI:

10.1073/pnas.88.6.2437

被引量:

431

年份:

1991

相似文献

参考文献

引证文献

研究点推荐

引用走势

1999
被引量:34

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用