A novel C-terminal kinesin subfamily may be involved in chromosomal movement in caenorhabditis elegans.
摘要：
C-terminal kinesin motor proteins, such as the Drosophila NCD and yeast KAR3, are involved in chromosomal segregation. Previously we have described two orthologs of NCD in Caenorhabditis elegans, KLP-3 and KLP-17, which also participate in chromosome movement. Here we report cDNA cloning of klp-15 and klp-16, and the expression pattern of the genes encoding C-terminal motor kinesins including klp-15 and klp-16. Interestingly KLP-15 and KLP-16 form a unique class of C-terminal kinesins, distinct from the previously known C-terminal motors in other organisms. Using in situ hybridization and RNA interference assay, we show that although all of these motors mediate chromosome segregation, they do so in a combination of unique and overlapping manners, suggesting a complex hierarchy of kinesin motor function in metazoans.
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关键词：
Kinesin-like protein Embryonic development C-terminal motor Cell division Chromosomal movement Caenorhabditis elegans
DOI：
10.1016/S0014-5793(00)01258-8
被引量：
年份：
2000
Elsevier
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ResearchGate
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core.ac.uk
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cghjournal.org
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