N-ACETYLHEXOSAMINE SULFUR DERIVATIVES AND USE OF SAME AS CELL TUMOR INHIBITORS
公开/公告号:
WO2011110723 A1
公开/公告日期:
Sep 15, 2011
摘要:
The present invention relates to a series of thioglycosides and to the oxidized sulfoxide and sulfone derivatives thereof, which provide better solubility in aqueous media, and to the use thereof as anti-tumor agents, principally against glioma and pulmonary adenocarcinoma cell lines. The novel thioderivatives are resistant to hydrolysis catalyzed by N-acetylhexosaminadases and reduce the ganglioside content of tumor cells. The invention likewise relates to a process for obtaining said compounds and to the use thereof in the manufacture of a medication for treating tumors.
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