摘要：

Experience with 50 poor-risk surgical patients has been presented, in whom neuroleptanaesthesia was used. The drugs employed were diazepam and morphine supplemented with nitrous oxide, d-tubocurare, and hyperventilation. The induction period was prolonged up to 3–5 minutes, with remarkably stable cardiovascular function. There was a progressive decrease in respiration, so that assisted and controlled ventilation was utilized. The blood gas values showed adequate arterial oxygenation, and a mild respiratory alkalosis. Routine curare-reversal was carried out at the termination of anaesthesia, with rapid return of consciousness and orientation, tranquility, amnesia, and analgesia persisted well into the recovery period, making this pleasant for the patient.It is recommended that in the poor-risk surgical patient, neuroleptanaesthesia with diazepam-morphine be administered with hyperventilation, but that provision be made to maintain normocarbia and normal acid-base balance.

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