Apoptosis and programmed cell death in immunity.
摘要：
Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal fragments. The cell is rapidly recognized by phagocytes and disposed of without releasing its contents. In some but not all cases of apoptosis, new macromolecular synthesis is required. Cytotoxic T cells induce changes in their targets that are morphologically apoptotic. The mechanism of apoptosis is currently under active investigation.
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DOI：
10.1146/annurev.iy.10.040192.001411
被引量：
年份：
1991
Semantic Scholar
NCBI
Oxford Univ Press
Europe PMC
Annual Reviews
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