A Human Placenta-specific ATP-Binding Cassette Gene (ABCP) on Chromosome 4q22 That Is Involved in Multidrug Resistance

来自 Semantic Scholar

喜欢 0

阅读量：

113

作者：

R Allikmets，LM Schriml，A Hutchinson，V Romano-Spica，MA Dean

展开

摘要：

We characterized a new human ATP-binding cassette (ABC) transporter gene that is highly expressed in the placenta. The gene, ABCP, produces two transcripts that differ at the 5' end and encode the same 655-amino acid protein. The predicted protein is closely related to the Drosophila white and yeast ADP1 genes and is a member of a subfamily that includes several multidrug resistance transporters. ABCP, white, and ADP1 all have a single ATP-binding domain at the NH2 terminus and a single COOH-terminal set of transmembrane segments. ABCP maps to human chromosome 4q22, between the markers D4S2462 and D4S1557, and the murine gene (Abcp) is located on chromosome 6 28-29 cM from the centromere. ABCP defines a new syntenic segment between human chromosome 4 and mouse chromosome 6. The abundant expression of this gene in the placenta suggests that the protein product has an important role in transport of specific molecule(s) into or out of this tissue.

展开

关键词：

Placenta Animals Humans Mice ATP-Binding Cassette Transporters Chromosome Mapping Reverse Transcriptase Polymerase Chain Reaction Drug Resistance, Multiple Organ Specificity Amino Acid Sequence