Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
摘要：
The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.
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关键词：
Animals Mice, Inbred C57BL Mice Macrophages Monocytes Hematopoietic Stem Cells Transcription Factors DNA-Binding Proteins Retroviridae Proteins, Oncogenic Mutation
DOI：
10.1126/science.8079170
被引量：
年份：
1994
万方医学
Semantic Scholar
dx.doi.org
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